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Bhaumik and colleagues [596] demonstrated that Bayesian modeling integrating both structural and functional MRI outperformed univariate approaches in detecting neuroprotective effects, especially in small or heterogeneous samples

Under conditions where antioxidant and iron-buffering systems are adequately engaged, NRF2 activation enhances GPX4, superoxide dismutase (SOD), and GSH levels, reduces lipid hydroperoxides, malondialdehyde (MDA), and ROS accumulation [118], and thereby suppresses ferroptotic cell death

The level of OS can be measured indirectly by detecting the oxidative or nitrosative products of lipids (malondialdehyde, 4-hydroxy-2-non-enal), proteins (protein carbonyls, 3-nitrotyrosine), or nucleic acids (8-Hydroxy-deoxyguanosine)

So, any spots or freckles on your body can be primarily considered blemishes

J Neurosci 25:1032110335