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Reactions were performed with 5 M histone H3 (histone L-arginine) substrate, 1 M radiolabeled S-adenosyl-L-[methyl-3H]methionine (SAM) co-substrate, and recombinant human PRMT3 enzyme

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It is actually one of the symptoms of pernicious anemia that people may notice first and is a symptom that may respond quickly to B12 supplementation