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The combination of rhodamine organic dyes and luminescent transition metal centers exhibits low cytotoxicity, increases tumor cell uptake, and enhances antitumor efficacy (154)

In addition, ROS contribute to this process

Rather, studies have shown that retinal exposure to multiple brief hypoxic stimuli and corresponding increases in cellular response molecules promotes sustained retinal hypoxia tolerance in a process called preconditioning (Tezel, 2006

Furthermore, IL8 signalling increases cell proliferation and survival to promote angiogenic responses in endothelial cells [38]

Despite the small sample size of this clinical trial, this results, as well as those of other clinical and preclinical trials, suggest that L-GSH supplementation has the potential to be an effective adjunctive therapy for the treatment of TB-DM ( Table 2 )