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The somatostatinergic system also encompasses cortistatin, an evolutionary-related peptide that shares high structural and functional similarity to somatostatin although derived from a distinct gene (de Lecea et al., Besides the initially described expression site in the hypothalamus, somatostatin is widely distributed in the rodent brain with dense expression in the cortex, amygdala, limbic and sensory system, periaqueductal central gray and paraventricular, ventromedial and arcuate hypothalamic nuclei (Finley et al., 1985

10.1186/s12891-025-09258-8 12 BagurR.HajnczkyG

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Alzahrani, T.F., Alotaibi, S.M., Alzahrani, A.A., Alzahrani, A.F., Alturki, L.E., Alshammari, M.M., Alharbi, R.A., Alanazi, S.I., Alshammari, W.Z

At the molecular level, CD38/cADPR signaling and MIRO GTPase expression vary across regions [136, 137]: cortical MFN2 upregulation enhances mitochondrial transfer to vascular endothelial cells, whereas age-related MFN2 decline in the cortex disrupts BBB integrity and impairs transfer