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Guinea pigs (Hartley, both sexes, 500-700 g b.w.) with whole body plethysmography, urethane anesthesia (1.5 g/kg i.p.), artificial ventilation under constant pressure (0.98 kPa), and relaxation of skeleton musculature by suxamethonium (0.2 mg/kg i.v.) were used in the present experiments

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Hydrogen gas is the primary byproduct

Furthermore, we embark on experimental endeavors to dissect the multifaceted impacts of key genes implicated in m6A modification in AD, scrutinizing their effects on biomarker expression and glycolytic metabolism across M1 and M2 macrophage subtypes