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Figure 4 Logistic regression analysis For CRC+ T2DM patients, sex, age, AGEs, RAGE, sRAGE, IGF1 and IGF1R were included to construct a multifactorial logistic regression analysis, and the results revealed that the effects of age, serum IGF-1 and IGF-1R on the occurrence of CRC in T2DM patients were statistically significant (all p 0.05) ( Figure 5 )