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Plant Antioxidants Participate in the Coordinated Protection of the Nervous System The nervous system is integrated with the entire human body, and plant-derived antioxidant substances are absorbed by the digestive system and then circulated throughout the body

40 Cardiovascular Subanesthetic doses of ketamine can cause changes in blood pressure and heart rate through several effects on the cardiovascular system

Consequently, free radicals accumulate substantially in the substantia nigra, and cytotoxic substances that cannot be cleared aggregate within neurons, ultimately leading to cell death and DA neurons [57]

However, the mechanism is yet to be determined

As shown in Table 4, supplementation of doses higher than 75 mg/kg bw show an adverse effect on the kidneys