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Metformin helps to maintain the BBBs integrity by reducing the apoptosis of endothelial cells, which form the barrier, and by enhancing the expression of tight-junction proteins, like occludins and claudin-5

Abnormal proliferation of cancer cells accompanied by exuberant nutrient metabolism is one of the main physiological characteristics of cancer, and starvation therapy has now become a current research hotspot in the field of oncology

Psychol Addict Behav 33(3):190 Persidsky Y et al (2006) Blood-brain barrier: structural components and function under physiologic and pathologic conditions

PEDF also significantly upregulates expression of BDNF, NGF, and nNOS, while downregulating proinflammatory cytokines (e.g., tumor necrosis factor [TNF], IL6, and IL1) [91]