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doi: 10.1016/j.freeradbiomed.2018.09.048 27 ChengY.SkinnerD

New Paradigms in Management of Metastatic Disease to the Lungs

One principal mechanism involves downregulation of key lipogenic enzymes, including fatty acid synthase (FAS) and ACC, which catalyze palmitate synthesis and the committed step of fatty acid biosynthesis, respectively

5 This led to the suggestion that polyphenol-mediated decrease in intrinsic GSH or efflux can sensitise lymphoid cancer cell lines to topoisomerase II inhibitors, which results in the synergistic and additive induction of apoptosis

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