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These results suggest that the knowledge of the molecular mechanism causing the transition of physiologically normal and soluble proteins to toxic oligomers and insoluble fibrils is essential for the development of treatment strategies

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SCFAs including butyrate also mitigate lipopolysaccharide (LPS)-induced barrier disruption by reversing decreases in TEER, reducing paracellular permeability, and restoring TJ morphology

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Siemens DR, Heaton JP, Adams MA, Kawakami J, Graham CH: Phase II study of nitric oxide donor for men with increasing prostate-specific antigen level after surgery or radiotherapy for prostate cancer