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As smooth muscle content decreases and collagen content increases, the smooth muscle-to-collagen ratio declines, reducing cavernous elasticity and impairing the veno-occlusive mechanism required for erection (138140)

451 Fisetin, another natural senolytic drug, has also been studied in the clinical stage (Table 3) for the treatment of age-related diseases, and its use is expected to lead to breakthroughs in the clinical research of senolytics

All reactions and procedures were essentially performed at RT

Thus, a consequential constant leak of microbial entities sustains a persisting low-grade systemic inflammation system referred to as inflammaging

Nucleic Acids Res 21(8):17271734