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however, overproduction of ROS can result in oxidative stress, negatively impacting immune cell functionality and undermining antitumor immunity

Moreover, as a patient-centered therapy, treatment adherence remains a major challenge of the KD

Although research on ferroptosis has deepened in recent years, the exploration of the epigenetic mechanisms regulating ferroptosis is still insufficient, and there are relatively few reference literatures

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CIRI is closely associated with perturbations in reactive oxygen species (ROS), which stem from inflammatory reactions, excessive calcium levels, and mitochondrial impairment [97]