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In a randomized clinical trial on patients with diabetic nephropathy accompanying chronic kidney disease, following NSO treatment, there was a significant reduction in blood glucose, serum creatinine, blood urea, and 24 h total urinary protein levels and an increase in glomerular filtration rate, 24 h total urinary volume, and hemoglobin level [140]

However, the problem is the poor reproducibility of quantitative methods, and therefore the application of oxLDL as a marker of oxidative stress in the prediction of cardiovascular diseases is doubtful

Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Abeta uptake and degradation by astrocytes

This suggests that Nrf2 may mediate expression of BDNF in cells comprising the vasculature and microglia to elevate the expression of antioxidant enzymes

Effects of N-acetylcysteine, oral glutathione and a novel sublingual form of GSH on oxidative stress markers