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2 Specifically, abnormalities in methylation, including methylation metabolites such as methionine, S-adenosyl-L-methionine (SAM) and S-adenosyl-L-homocysteine (SAH) are present in this population

The latter report suggests that lipid membrane fragments and distorted organelles, together with a non-fibrillar form of Syn, are the main structural components of LBs and that they do not contain fibrillar Syn aggregates

That study revealed that ferrylHb but not Hb or metHb induce active IL-1 production in LPS-primed macrophages in an NLRP3-dependent manner ( Hemorrhage-Associated Macrophage Subsets Besides the two extreme canonical macrophage phenotypes, the pro-inflammatory M1 and the anti-inflammatory M2, many other specific and distinct macrophage subsets exist (103)