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A deficiency in vitamin B12 has a significant impact on homocysteine levels, which is an amino acid that is linked to increased oxidative stress as well as potential liver damage

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Moreover, we observed that leucine exacerbated hepatocyte injury through activating the Hippo signaling pathway, especially the overexpression of YAP1, while probiotics composed of Gram-positive bacteria could reverse this process

There are several different types of PCD, classified based on the mechanisms involved and stimuli that trigger the process