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198 In the context of obesity, increased hepatic expression of the unconventional prefoldin RPB5 interactor (URI) has been shown to couple nutrient surplus with inflammation, leading to nonalcoholic steatohepatitis (NASH) and consequent HCC

In those preclinical models, BPC-157 has been associated with effects on angiogenesis, on growth-factor expression including VEGF and FGF, and on the nitric oxide system

doi:10.22074/cellj.2016.4872 [21] Barreiro E, Snchez D, Gldiz JB, Hussain SN, Gea J

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In contrast, the symbiotic fungus Fusarium foetens ameliorates MASH via its metabolite FF-C1-mediated CerS6 inhibition, reducing ceramides and improving steatosis, inflammation, and fibrosis 55