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Variants of this gene are also involved in medication resistance to antiviral and anticancer drugs.[ref] The wet earwax allele was also associated with a higher risk of breast cancer in Japanese women but not in women of European descent.[ref][ref][ref] In Japanese men, carrying the allele associated with wet earwax is linked with an increased risk of hidradenitis suppurativa .[ref] Hidradenitis suppurativa is a painful skin condition causing pus-filled lumps under the skin, usually in the underarms, buttocks, or groin areas

This robust upregulation and stabilization of HIF-1 ultimately drives the transcription of VEGF, dramatically stimulating endothelial cell proliferation and tumor angiogenesis

doi: 10.1016/j.braindev.2007.03.002

10.3746/pnf.2018.23.3.171 [DOI] [PMC free article] [PubMed] [Google Scholar] Appia-Ayme C, Little R, Chandra G, de Oliveira Martins C, Bueno Batista M, & Dixon R (2022)

Endocrinology 141 : 42554261 Sato T et al