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One to seven days at controlled room temperature (below 86 degrees Fahrenheit) consumes a significant portion of the 21-day allowance but does not automatically render the medication unusable

J Biol Chem (1994) 269(20):1483540

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In a similar study of switch to open-label DOR/ISL from various regimens, weight gain was observed on DOR/ISL through 48 weeks but was driven by removing weight-suppressive ART (i.e., EFV or TDF) in stratified analyses [22]