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The duration of the trial was three years with 3862 patients exposed to Reclast and 3852 patients exposed to placebo administered once annually as a single 5 mg dose in 100 mL solution infused over at least 15 minutes, for a total of three doses

This equalizes the pressure, making the water addition smooth and controlled

The proportion of participants achieving 20% or greater weight loss was 36% at the 10mg dose and 40% at the 15mg dose, results approaching what was previously achievable only with bariatric surgery

In the United States, the FDA regulates drugs for human use, but vendors selling compounds labelled for research purposes only operate in a grey zone that makes straightforward enforcement difficult