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Three structural features a lid domain, a glycine-rich loop, and an alanine-rich loop define the active site of hGS (Figure 4B)

More recently, Xiong and his team found that impaired epoxyeicosatrienoic acid (EET) signaling can impede ATP release from astrocytes in the mPFC, inducing depressive-like behavior (Xiong et al., 2019)