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Two large RCTs, The Investigation for Maximal Peyronis Reduction Efficacy and Safety Studies (IMPRESS) I and II, examined the efficacy and safety of intralesional clostridial collagenase in the treatment of PD and obtained high-level evidence ( Although patients with penile curvature from 30 to 90 were included in IMPRESS I/II and the deformity were corrected for mean 17 in CCH-treated group, greater overall satisfaction of IIEF was also achieved in treatment group, indicating that the improvement in satisfaction is associated not only with reduced curvature but also objective elements

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J Pain 12(12):1282-88, 2011