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Notably, human genome-wide association study (GWAS) data have shown that single-nucleotide polymorphisms in the vicinity of the TGFBI gene are associated with type 1 diabetes risk, and TGFBI has been shown to promote islet survival, function and regeneration in mice [43]

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Akt is a critical kinase downstream of IGF-I action and most of IGF-Is anabolic and anti-apoptotic effects are mediated by phosphorylation and activation of Akt

Similarly, the anti-apoptotic effect of SCF and IL-3 on erythroid precursors is also mediated by PI3K/Akt and JAK/STAT signaling pathways [102, 110]