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This is the core argument for lower concentrations when microdosing: the math has to work with the tools you actually have

Hosaka M, Watanabe T, Sakai Y, Kato T, Takeuchi T (2005) Interaction between secretogranin III and carboxypeptidase E facilitates prohormone sorting with in secretory granules

Viability and cytotoxicity are inversely proportional such that if the viability of cells is reduced, cytotoxicity is usually stimulated and programmed cell death, apoptosis, is either induced or not induced

This amphiphilic balance influences solubility behavior in organic solvents and mixed aqueous-organic systems

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