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Description

Side effects vary by hormone and delivery method

To prevent side effects in this extremely sensitive and vascular area, we prefer to use a cannula (a blunt-tipped tube that can reduce swelling and bruising)

This is a documentation rule as much as a storage rule

Specifically, we show that AR directly represses BCL-2 transcription via binding to multiple ARBS across the BCL-2 genomic region, especially the ARBS1 around the promoter, and castration and ARPI treatment block AR engagement to most ARBS leading to de-repression of BCL-2 transcription