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We observed no detectable production of d3-isotopologues of betaine, glycine, or 3-dehydrocarnitine in either plasma (multiple time points between 024 hours) of C57BL/6J female mice challenged (gastric gavage) with d3-carnitine or in the ex vivo gut segment incubation experiments under either anaerobic or aerobic conditions (Figure S3, and data not shown)

Owing to this large age gap, the beneficial effect of dexamethasone may have been partly masked in the older adult cohort

Morais P., Adachi H., Yu Y.T

doi: 10.1093/ajcn/37.2.185 211