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Singh S, Diwaker A, Singh BP, Singh RK

IGF-1 LR3 activates IGF-1 receptors and initiates the PI3K/Akt/mTOR cascade - the primary regulatory pathway responsible for muscle hypertrophy, protein synthesis, and tissue repair

Increased metabolic activity in young brains of APO E4 carriers may drive the classical AD pathology and contribute to the accumulation of -amyloid aggregates and phospho-tau [97] leading to neuroinflammation, synapse loss and neurodegeneration