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RSL3 is able to induce ferroptosis by directly inhibiting the enzymatic activity of GPX4 through covalent interaction with selenocysteine at the active site of GPX4 (51)

Lancet Planet Health 5, e560e569

Despite these promising clinical data, JAKinibs should be used with caution because of their side effects, based on the following considerations: (1) nonselective inhibition of the JAK/STAT pathway increases the risk of secondary infection such as herpes zoster virus reactivation given its general inhibitory effects on multiple aspects of physiological actions, including the innate immune system

Alterations of renal fatty acid metabolism in cKOt mice

Loss-of-function GSTM2 mouse model demonstrated that GSTM2 protected mice from excess fat accumulation