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Figure 1 Accordingly, nave CD4 + T cells isolated from RA patient exhibit diminished glycolytic activity ( + T cells become pathogenic memory and effector T cells, they utilize glucose in a distinctly different manner than nave CD4 + T cells from healthy individuals: they avoid glycolytic breakdown into lactate and instead divert glucose into the PPP, driving the accumulation of NADPH and consumption of cellular reactive oxygen species (ROS)

Zgair A, Dawood Y, Ibrahem SM, Back H, Kagan L, Gershkovich P, Lee JB

Resveratrol modulates the Akt/GSK-3 2 signaling pathway in a middle cerebral artery occlusion animal model

The meta-analytic evidence is clear that subgroup nuances matter enormously

Front Neuroenergetics 3:9