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found that KRAS mutation could upregulate AURKA and TPX2 in PDAC cells to promote rapid PDAC cell proliferation ( KRAS mutation can lead to the spontaneous loss of GATA6 , which may result in pancreatic acinar differentiation program GATA6 dysregulation and also upregulate epidermal growth factor (EGFR), an upstream activator of KRAS

Further, we found this decreased serum triglyceride levels to be reversed when mice were placed on an HFD (Fig

(PubMed) Eskin BA, Grotkowski CE, Connolly CP, Ghent WR

Catalytic and structural contributions for glutathione-binding residues in a Delta class glutathione S-transferase

De Grey AD (2002) HO2*: the forgotten radical