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(2017), reported that RPM supplementation was effective for multiparous, while no significant impact was observed in primiparous cows

The result is a slow, progressive B12 shortfall even when dietary intake is adequate

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Combination treatments (multi-target protocols often exceed single treatments)

Conditions of Paradoxical B12 deficiency include Autism Chronic Fatigue Syndrome Hypothyroidism Parkinson's Disease Various malignancies Inflammatory Conditions Various cancers Ulcerative colitis Long Covid Persons with Paradoxical B12 deficiency are more likely to die from COVID-19 Persons with Paradoxical B12 deficiency more likely to die from all cause mortality The current dogma on vitamin B12 deficiency implies a direct link between levels of serum vitamin B12, and sufficiency