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Rather than acting through a single pathway, amylin appears to function as part of an integrated physiological system that contributes to nutrient sensing and energy regulation

Bielak-Zmijewska, G

Proceedings of the National Academy of Sciences of the United States of America, 94 (5), 1967

A dedicated phase 2a substudy in people with obesity and metabolic dysfunction-associated steatotic liver disease (MASLD) used MRI to measure liver fat and found that, after 24 weeks, retatrutide reduced relative liver-fat content by about 81% at the 8 mg dose and about 82% at 12 mg, versus essentially no change on placebo

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