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261 When IT therapies are combined with ICIs, systemic immune-related adverse events (irAEs), such as hepatitis, pneumonitis, or thyroiditis, may occur, highlighting the need for adaptive dosing, step-up schedules, and close clinical monitoring

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Expect at least 46 weeks of treatment for most cases

Apoptosis describes a programmed mode of cell death that is characterized by a series of biochemical events that ultimately lead to cell fragmentation into compact membrane-enclosed structures, called apoptotic bodies that are taken up by neighboring cells and phagocytes, preventing inflammation, and tissue damage (Taylor et al., 2008)

Seek urgent medical attention if you experience severe abdominal pain, jaundice, signs of dehydration, or difficulty breathing, as these may indicate serious adverse effects such as pancreatitis or gallbladder disease