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Essentially these 2 categories could be regarded on a single continuum of visceral dysfunction, with disorders of function at one end and frank pathologic conditions at the other end

-defensins (HD-5 and HD-6), expressed mainly by Paneth cells in the small intestine, and -defensins (hBD1 to hBD-4), expressed by epithelial cells throughout the intestine, possess antimicrobial activity against a wide range of variety of bacteria, fungi, and some viruses and are constitutively expressed to prevent pathogens from reaching the epithelium