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Dysfunction of the intestinal epithelial barrier and increased permeability results in a leaky gut that is associated with intestinal disorders such as inflammatory bowel disease (IBD), bowel syndrome irritable liver disease (ILD), alcoholic liver disease, nonalcoholic fatty liver disease, steatohepatitis, liver cirrhosis, and collagen diseases (Figure 2)

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Curcumin prevents high-fat diet-induced hepatic steatosis in apoe/ mice by improving intestinal barrier function and reducing endotoxin and liver tlr4/nf-b inflammation