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Emerging agents offer promising opportunities for improved disease characterization, patient stratification, and individualized treatment planning

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While there were no statistical differences between untreated and A42, the number of terminals trended toward increased counts per volume with all of the A treatments when compared with untreated, with only the counts per volume significantly increased with treatment combined treatment with ACore and A42 (Fig

These cells not only retained mitotic capacity, but also maintained a more youthful morphology and gene expression profile, indicating real preservation of cellular youth

Together, these findings support the role of vitamin D in modulating immune and inflammatory responses in CKD through multiple pathways and highlight its close connection to oxidative stress, which will be discussed in the next section