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Moreover, SLC3A2 affects polyamine uptake in neuroblastoma by reducing spermidine uptake and utilization and thus delaying tumor development in neuroblastoma-prone mice [288]

Pharmacokinetic properties of AC Elucidating the pharmacokinetic characteristics is critical for predicting drug distribution in vivo, as well as for evaluating drugs therapeutic effects, adjusting doses, and using drugs rationally

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In the study by Corral-Jara et al., the researchers employed a multi-omics approach and discovered that EC metabolites derived from the gut microbiota, particularly -pentalactone-bound metabolites, exert significant anti-inflammatory effects by synergistically regulating mRNA, miRNA, lncRNA, and protein expression

The enzyme indole-2,3-dioxygenase 1 (IDO1) in the first committed step of the de novo synthesis pathway metabolizes tryptophan to the immunosuppressive metabolite kynurenine in the context of immune challenges [27,28,29]