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J., et al., 2006, American Journal of Medical Genetics Part B (Neuropsychiatric Genetics), 141B: 947-956)

Kano, M

Furthermore, mitochondrial dysfunction in the neurons of aged mice (12-month-old) resulted in decreased production of ATP and increased production of ROS, which may subsequently damage oligodendrocytes and OPCs over time, thereby preventing OPC differentiation and myelination (Stahon et al., 2016