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In a given multicenter trial, 11 percent of sites fail to enroll a single patient, 37 percent of sites do not meet enrollment targets, and studies are typically lengthened (often to double the original timeline) to satisfy enrollment targets [3]thereby constituting a significant use of resources to launch clinical trials that fail or struggle to reach the desired return on that investment

To confirm whether NIR emission was associated with TGF- signaling and collagen biosynthesis, we exposed HaCaT cells and HDF cells to NIR for 20 min, and the expression of collagen biosynthesis genes was measured by real-time PCR

These studies have indicated that protein methylation, such as H3K9 and H3K27 methylation, is a critical epigenetic mechanism in the regulation of ferroptosis (Figure 5B and 5D)

Data are expressed as the mean standard deviation (SD) from at least three independent experiments

We also acknowledge the German Cancer Research Center Genomics and Proteomics Core Facility, which helped us to obtain high-quality data for the sequencing and DNA methylation analyses