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doi: 10.1016/j.jep.2018.08.037 59 KoulisCWatsonAMDGraySPJandeleit-DahmKALinkingRAGE

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All direct vasodilators produce a sympathetic response including an increase in heart rate, stroke volume, and cardiac output, and a marked increase in plasma renin activity, which, in turn, leads to increased sodium and water retention