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doi: 10.3389/fpsyt.2022.813304 Received 12 November 2021 Accepted 24 January 2022 Published 01 March 2022 Volume 13 - 2022 Edited by Ignazio Piras, Translational Genomics Research Institute (TGen), United States Reviewed by Ahmed Nadeem, King Saud University, Saudi Arabia

Given the complexity of mechanisms involved in drug resistance and survival pathways of tumor cells, combination strategies of GSH-conjugates with conventional chemotherapy or targeted drugs should provide very interesting perspectives for the treatment of drug resistant tumors

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238 This complicates mechanistic interpretation and may lead to false-positive or irreproducible findings in high-throughput screening