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17 Currently, there is still a lack of consensus regarding the diagnosis or management of HAD, making it challenging to accurately delineate its prevalence and pathogenic mechanisms

Ethics declarations Conflict of interest The authors declare they have no conflicts of interest

GPX7 can transmit oxidative stress signals by forming disulfide bonds between its catalytic sites Cys57 and Cys86 residues, and this oxidized form of GPX7 can bind to each other with GRP78 and form covalent bond intermediates between Cys86 of GPX7 and Cys41/Cys420 of GRP78 (Nguyen et al., 2011

Among these foods are omega-3 fatty acids, polyphenol-rich fruits and vegetables, lean protein sources, herbs, and green tea

Unlike conventional treatments that simply reduce acid production, BPC-157 works to repair the physical mechanisms that allow acid to escape into the esophagus