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In contrast, but with ultimately the same result, impairment of transsulfuration will lead to increased intracellular SAM concentrations and consequent inhibition of MTHFR, which reduces the formation of 5-methyltetrahydrofolate for remethylation and inhibits recycling of homocysteine through its conversion to methionine (16)

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The gastric epithelium is considered to have greater tightness, depending on the number and depth of tight junction strands, than the esophageal epithelium

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PMID 10448529