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or it may be from something completely different

The NHS weight loss plan focuses on sustainable lifestyle modifications, including: Calorie reduction through portion control and healthier food choices Increased physical activity (minimum 150 minutes moderate-intensity exercise weekly, plus muscle-strengthening activities at least twice weekly) Behavioural strategies and goal-setting Referral to specialist weight management services based on local criteria Referral thresholds for weight management services vary by locality

7 Similarly, in the CASTOR clinical trial, patients with relapsed or refractory multiple myeloma who received the combination of daratumumab with bortezomib and dexamethasone had significantly prolonged PFS relative to those who received bortezomib and dexamethasone alone

This is particularly relevant for people taking weight loss injections, such as GLP-1 agonists (e.g., Ozempic or Mounjaro), which can sometimes cause fatigue and a feeling of low energy

Molecular analysis Figure 2 illustrates the identified (likely) pathogenic variants