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The study on rhesus monkeys identified dose-dependent renal (kidney) toxicity as the primary limiting factor

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I don't think there are any formal guidelines in UK for the treatment of children with B12 deficiency

Only in severe deficiency cases, neurological complications can indirectly contribute to joint discomfort

Furthermore, this trend toward increased alpha diversity in the obese groups placed on an LD that had consequently experienced weight loss aligns with clinical observations, where low gene richness has been associated with increased adiposity, insulin resistance, and dyslipidemia 70 while increased gene richness has been observed following dietary intervention in obese and overweight individuals 71