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The bioavailability differs, the dosing schedule changes from weekly to daily, and the evidence base is less robust

The escalation schedules that showed the best balance of efficacy and tolerability followed this general pattern: Weeks 1 through 4: 2mg once weekly

Chery, Celine, et al

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Finally, poor oral bioavailability, incomplete toxicology, uncertain long-term effects, and the absence of controlled human trials remain major limitations