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the invention encompasses use of one or more cations of the invention to treat obesity or related chronic metabolic condition, including metabolic syndrome, pre-diabetes, type-2 diabetes, obesity-linked diseases (e.g., non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, CVDs, and the like)

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Route: Oral (arginine salt form preferred) Dose: 0.5 to 1 mg daily Timing: On empty stomach for best absorption Duration: 4 to 8 weeks typical Expected timeline: 1 to 2 weeks for initial improvements User reports describe improvements in bloating, digestive discomfort, and bowel regularity within one to two weeks, with full therapeutic benefit emerging over four to six weeks

[DOI] [PubMed] [Google Scholar] 27.Caplan RH, Davis K, Bengston B, Smith MJ