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Metabolically, CB-839 effectively inhibited OCR and ATP production in both cell lines, providing evidence of CB-839s mechanism of action in CLL cells

Fluorescence imaging was performed under a confocal microscope (Zeiss LSM 810, Germany or Nikon AXR, Japan), and immunohistochemistry imaging was performed under a microscope (Nikon Eclipse SI)

High alcohol consumption activates microglia and dramatically increases ROS production (Qin and Crews, 2012), which can, in extreme situations, affect the fluidity of the mitochondrial membrane, resulting in functional changes and an increase in oxidant production (Haorah et al., 2011)

Hoppe C, Mlgaard C, Juul A, Michaelsen KF

The enzyme tyrosinase, usually present in an inactive form, is formed in these melanocytes