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Autoimmunity Autoimmune diseases occur when the immune system mistakenly attacks healthy cells, leading to chronic inflammation, tissue damage, and immune dysfunction

In summary, ubiquitination regulates the initiation, progression, and termination of DDR, and controls the switch between different types of cellular responses, which makes DDR an elegant and accurate machinery

In type 2 diabetes management, for example, NICE guideline NG28 supports the use of multiple agents with complementary mechanisms when monotherapy is insufficient

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NORSE and FIRES are defined below: Epilepsia partials continua (EPC) is defined & discussed here: NORSE NORSE definitions New-onset Refractory Status Epilepticus (NORSE) : New-onset seizure with refractory status epilepticus (i.e., refractory to two medications such as benzodiazepine plus levetiracetam)