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While Dihexa-specific desensitization kinetics haven't been thoroughly characterized in long-term studies, applying known c-Met receptor regulation patterns suggests daily dosing beyond 46 weeks without rest periods would likely produce diminishing returns

However, targeting specific gut microbiota with antifungals often yields unsatisfactory results, as some drugs are rapidly metabolized and fail to reach the lower digestive tract 167

Pal et al., 2022)

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