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Description

Microglia possess the capability to detect microorganisms, leukocytes, and their metabolites, such as LPS, granulocytemacrophage colony-stimulating factor (GM-CSF), and can swiftly initiate an immune response by secreting IL-1, IFN-, and TNF-

The side effect profiles of cagrilintide and retatrutide are broadly consistent with other incretin-based therapies, reflecting their shared mechanisms of action

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Two strategies dominate: structural stabilization (modifications that resist proteases) on one side, and small non-peptide agonists that mimic a peptide's action without its fragility on the other